Male sex, active smoking and previous intestinal resection are risk factors for postoperative endoscopic recurrence of Crohn’s disease, according to a study in Alimentary Pharmacology and Therapeutics.
Here are four things to know:
1. Between September 2010 and September 2017, researchers conducted a study of 289 Crohn’s disease patients at nine French academic medical centers. Study authors collected data at the time of surgery and between six and 12 months postoperatively during endoscopy procedures.
2. Endoscopy within one year following surgery was performed in 78 percent of patients, and 32 percent of patients were active smokers at surgery. More than half — 63 percent — of patients received at least one anti-tumor necrosis factor therapy preoperatively.
3. After surgery, 18 percent of patients received thiopurines, and 29 percent received an anti-TNF agent. Endoscopic recurrence occurred in 47 percent of patients.
4. Male sex, active smoking at surgery and previous resection were associated with a higher risk of endoscopic recurrence, while postoperative anti-TNF treatment was associated with a lower risk.