Protein Biomarker Linked to Better Colorectal Cancer Survival for Obese

Activation of the protein biomarker CTNNB1 in obese patients was associated with better survival from colorectal cancer and overall survival, according to a study in the Journal of the American Medical Association.

Activation of the WNT signaling pathway, a network of proteins linked to cancer processes, and cadherin-associated protein beta-1 (CTNNB1) play a critical role in colorectal carcinogenesis, stories have shown.

Growing evidence indicates a role of WNT-CTNNB1 signaling in obesity and metabolic diseases. Considering the dual roles of CTNNB1 in carcinogenesis and energy metabolism, the authors hypothesized that activation of WNT-CTNNB1 signaling might provide proliferative ability to cancer cells.

In the study, obese patients with positive status for nuclear CTNNB1 were associated with significantly better colorectal cancer-specific survival and overall survival. Among non-obese patients, in comparison, positive status for nuclear CTNNB1 was not significantly associated with cancer-specific survival or overall survival.

Read the JAMA Abstract on colorectal cancer.

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