Non-Infiltrative Anesthetics Effective in Treating Transrectal Prostate Biopsy Pain

Non-infiltrative anesthetics are safe and effective in treating pain from transrectal prostate biopsy, according to research from the Department of Urology and Renal Transplantation at the University of Foggia in Italy.

According to the study's abstract, periprostatic nerve block is the standard anesthesia for ultrasound-guided transrectal prostate biopsy, but periprostatic infiltration creates a major source of discomfort for patients. Non-infiltrative anesthesia therefore presents an attractive alternative to periprostatic infiltration.

The researchers aimed to determine the effectiveness and safety of perianal-interrectal lidocaine gel, lidocaine-ketorolac gel and lidocaine-prilocaine cream in relieving pain. Three-hundred consecutive patients scheduled for US-guided TPB were randomized to receive one of the treatments.

The study found that lidocaine-prilocaine cream was most effective on probe-related pain, whereas lidocaine-ketorolac gel was most effective on sampling-related pain.

Read the abstract in UroToday on the study on non-infiltrative anesthetics.

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