German researchers found a mutation in the TFAP2E gene might play a part in chemo-resistant colorectal cancer, according to findings published in the New England Journal of Medicine.
By analyzing the gene in 220 patients, the researchers determined how the gene functioned within colorectal cancer tumors and concluded that hypermethylation —the addition of methanol — of the TFAP2E gene is associated with clinical resistance to chemotherapy in colorectal cancer. Among the first group of 74 patients the researchers studied, 38 had the mutation of the gene.
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By analyzing the gene in 220 patients, the researchers determined how the gene functioned within colorectal cancer tumors and concluded that hypermethylation —the addition of methanol — of the TFAP2E gene is associated with clinical resistance to chemotherapy in colorectal cancer. Among the first group of 74 patients the researchers studied, 38 had the mutation of the gene.
Related Articles on Colorectal Cancer:
Roper St. Francis Healthcare First in South Carolina to Use da Vinci robot With Firefly Fluorescence Imaging in Colon Cancer Surgery
Dr. Peter Apicella: Colon Cancer Detection Improved With Virtual CT Colonoscopy
Obese Patients Less Likely to Have Genetic Mutation Associated With Better Colorectal Cancer Outcomes