FDA has issued a drug safety communication noting the use of proton pump inhibitors may be associated with an increased risk of Clostridium difficile–associated diarrhea.
Patients are advised to immediately contact their healthcare professional and seek care if they take PPIs and develop diarrhea that does not improve.
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Providers are advised to consider a diagnosis of CDAD for PPI users with diarrhea that does not improve.
FDA said it is working with manufacturers to include information about the increased risk of CDAD with use of PPIs in the drug labels. FDA also said it is reviewing the risk of CDAD in users of histamine H2 receptor blockers.
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