Hemifluorinated dibranched polymers can be used to generate exceptionally stable sevoflurane nanoemulsions, according to a study published in the March issue of Anesthesiology.
Researchers tested the emulsion stability by using dynamic light scattering. The ability of the emulsions to induce anesthesia was then tested by administering them to rats through an IV and measuring loss of the forepaw righting reflex.
The study found that IV delivery of the emulsion in rats resulted in induction of anesthesia with rapid onset and smooth recovery.
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Researchers tested the emulsion stability by using dynamic light scattering. The ability of the emulsions to induce anesthesia was then tested by administering them to rats through an IV and measuring loss of the forepaw righting reflex.
The study found that IV delivery of the emulsion in rats resulted in induction of anesthesia with rapid onset and smooth recovery.
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