Multibiomarker risk prediction model for Barrett's esophagus: 5 things to know

A recent study published in the journal Clinical Gastroenterology and Hepatology examined the role a multibiomarker risk score can play in predicting the possibility of Barrett's esophagus. Here are five things to know about the study.

•    The study included 141 patients with confirmed BE and 138 control patients.
•    The study compared three different risk models. The first was based only on GERD frequency and duration. The second included GERD frequency and duration, age, sex, race, waist-to-hip ratio and H. pylori status. The third included all of the variables of the second model, as well as a multibiomarker risk score.
•    The multibiomarker risk score was based on serum levels of interleukin (IL) 12p70, IL6, IL8, IL10 and leptin.
•    Patients with a multibiomarker risk score of three or higher, in comparison to patients with a score of zero, had a 10-fold increased risk for BE.
•    The study authors concluded that the addition of a multibiomarker risk score to previous methods may be more accurate than previous methods alone.

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