Prophylactic antibiotic choice impacts the risk of surgical site infection rates in women undergoing hysterectomy, according to a study published in Obstetrics & Gynecology.
Researchers at the University of Michigan in Ann Arbor and the University of Wisconsin in Madison, as well as other institutions, conducted a retrospective cohort study of 21,358 hysterectomies performed from July 2012 to February 2015. Patients receiving a recommended preoperative antibiotic regimen were categorized into those receiving β-lactams and those receiving an alternative antibiotic. Patients receiving non-recommended antibiotics were categorized into those receiving over treatment and those receiving nonstandard antibiotics.
Here are five points:
1. The overall rate of SSI was 2.06 percent.
2. The unadjusted rates of SSI were 1.8 percent, 3.1 percent and 3.7 percent for β-lactam, β-lactam alternatives and nonstandard groups, respectively.
3. After adjusting for patient and operative factors with clusters of hospitals, as compared with the β-lactam antibiotics, the risk of any SSI was higher for the group receiving approved β-lactam alternatives or the nonstandard antibiotics.
4. SSIs may be the most frequent healthcare-associated infection after asymptomatic bacteriuria.
5. Each year, approximately 500,000 surgical patients develop SSIs.
