Boise (Idaho) State University researchers have created a new vaccine that shows high promise in preventing Staphylococcus aureus, a bacterium that can cause a range of illnesses such as skin infections and pneumonia.
Each year, nearly 500,000 Americans are admitted to hospitals for staph infections. Research shows that more than 50 percent of those are from MRSA, which is resistant to current antibiotics.
Boise State biology scientists created a vaccine that uses a cholera toxin molecule called A2/B chimera, which also contains an iron-regulated surface determinant from S. aureus.
The research team studied the immune response in 24 mice that were given the vaccine they created and measured how many antibodies the mice produced against staph over 45 days. The results showed the mice had a significant number of antibodies against staph, although a booster dose was needed after the 10th day.
Boise State researchers will now attempt to do a much larger protection study with mice to continue to measure the effectiveness of the vaccine.
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Each year, nearly 500,000 Americans are admitted to hospitals for staph infections. Research shows that more than 50 percent of those are from MRSA, which is resistant to current antibiotics.
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Boise State biology scientists created a vaccine that uses a cholera toxin molecule called A2/B chimera, which also contains an iron-regulated surface determinant from S. aureus.
The research team studied the immune response in 24 mice that were given the vaccine they created and measured how many antibodies the mice produced against staph over 45 days. The results showed the mice had a significant number of antibodies against staph, although a booster dose was needed after the 10th day.
Boise State researchers will now attempt to do a much larger protection study with mice to continue to measure the effectiveness of the vaccine.
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